解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
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传染病
综合和补充性医学
医学伦理学
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病毒学
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健康政策和服务
心理学,临床
abstract::Several cis-acting elements regulate the expression of germline transcripts of heavy chain constant region genes and their subsequent switch recombination. To study such elements in the murine gamma1 gene, we have utilized a transgenic approach. In this study we focused on a DNase I hypersensitive site (termed 'Site I...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.12.1705
更新日期:2000-12-01 00:00:00
abstract::Dendritic cells (DC) are potent antigen-presenting cells and understanding their mechanisms of antigen uptake is important for loading DC with antigen for immunotherapy. The multilectin receptors, DEC-205 and macrophage mannose receptor (MMR), are potential antigen-uptake receptors; therefore, we examined their expres...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.11.1511
更新日期:2000-11-01 00:00:00
abstract::Evidence from several different experimental systems suggests that regulatory cells specific for self-antigens exist in the normal immune repertoire, and that these cells are necessary for maintenance of self-tolerance and prevention of autoimmune disease. We attempted to demonstrate the existence of regulatory cells ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.11.1605
更新日期:2000-11-01 00:00:00
abstract::Mercury-induced autoimmunity is characterized by a T cell-dependent B cell activation (mainly of IgG1 and IgE isotypes), production of anti-nucleolar autoantibodies (ANolA) and the formation of renal IgG deposits. The autoimmunity is to a large extent controlled by genetic factors. We studied 15 different inbred mouse...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.10.1425
更新日期:2000-10-01 00:00:00
abstract::Myasthenia gravis (MG) is an autoimmune disease, caused by autoantibodies against the muscle acetylcholine receptor (AChR), an oligomeric transmembrane glycoprotein composed of alpha(2)beta gamma delta subunits. The alpha subunit carries in its N-terminal extracellular domain the main immunogenic region (MIR), a group...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.9.1255
更新日期:2000-09-01 00:00:00
abstract::Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.9.1347
更新日期:2000-09-01 00:00:00
abstract::The association of celiac disease (CD) with HLA-DQ2 and HLA-DQ8 is indicative of preferential mucosal T cell recognition of gluten fragments bound to either DQ allele. We have recently identified two gluten-derived, HLA-DQ8-restricted T cell stimulatory peptides, one each from gliadin and glutenin, recognized by speci...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.8.1157
更新日期:2000-08-01 00:00:00
abstract::In vivo administration of NKT cell ligand, alpha-galactosylceramide (alpha-GalCer), caused the activation of NKT cells to induce a strong NK activity and cytokine production by CD1d-restricted mechanisms. Surprisingly, we also found that alpha-GalCer induced the activation of immunoregulatory cells involved in acquire...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.7.987
更新日期:2000-07-01 00:00:00
abstract::Immunoglobulin (IG:) genes are hypermutated in mature B cells after interaction with antigen and T cells in a germinal center reaction. We and others have recently shown that the human BCL6 gene is also hypermutated in human peripheral blood memory B cells and tonsils. A preliminary analysis of other non-Ig genes (c-M...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.7.1085
更新日期:2000-07-01 00:00:00
abstract::Intradermal inoculation of plasmids expressing antigens that contain MHC class I-restricted epitopes leads to the induction of specific CD8(+) cytotoxic T lymphocytes (CTL). The role of in situ transfected antigen-presenting cells (APC) in the priming of specific CTL subsequent to intradermal DNA immunization was inve...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.6.825
更新日期:2000-06-01 00:00:00
abstract::In the genetic disorder ataxia telangiectasia (AT), humoral (B) and cellular (T) immunological abnormalities are frequently observed. As a consequence, AT patients are predisposed to life-threatening sinopulmonary infections. The pathogenic mechanisms remain unknown, but a role for ATM in signal transduction from memb...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.6.927
更新日期:2000-06-01 00:00:00
abstract::A gelatin sponge model of concomitant tumor immunity was employed in order to examine the clonality of T cells associated with progressing and rejected tumor sites. Here we show that freshly isolated T cells bearing TCR V(beta)1, CDR3 RPGTGN, J(beta)1.1 and TCR V(beta)8, CDR3 GD, J(beta)1.6 predominated progressing an...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.5.639
更新日期:2000-05-01 00:00:00
abstract::Soluble recombinant (r) P-selectin and rP-selectin immobilized on plastic surfaces were tested for their capacity to activate neutrophils to produce superoxide anion. Soluble rP-selectin was incapable of activating leukocytes, whereas immobilized rP-selectin was able to induce leukocyte activation. When neutrophils we...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.4.487
更新日期:2000-04-01 00:00:00
abstract::We have recently described the novel A6H antigen expressed on human peripheral blood T cells and on renal cell carcinoma cells. Cross-linking of the A6H antigen results in co-stimulation of human CD4(+) T cells, characterized by induction of the transcription factor activator protein-1 (AP-1), proliferation and promin...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.3.253
更新日期:2000-03-01 00:00:00
abstract::bcl-2 transgenic mice develop anti-double-stranded (ds) DNA antibodies similar to those present in systemic lupus erythematosus. To begin to understand where a breakdown in the regulation of autoreactive lymphocytes is occurring, we have used a bcl-2 transgene (Tg) in conjunction with an Ig Tg that allows us to identi...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.3.353
更新日期:2000-03-01 00:00:00
abstract::IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T(h)1 response. IL-18 has a structural homology to IL-1, particularly IL-1beta. IL-18R, composed of IL-1R-related protein (IL-18Ralpha) and IL-1R accessory protein-like (IL-18Rbeta), belongs to the IL-1R family. Furthermore, IL-...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.2.151
更新日期:2000-02-01 00:00:00
abstract::Antigen-coupled antigen-presenting cells (APC) serve as potent tolerogens for inhibiting immune responses in vivo and in vitro, apparently by providing an antigen-specific signal through the TCR in the absence of co-stimulation. Although this approach has been well studied in rodents, little is known about its effects...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.1.57
更新日期:2000-01-01 00:00:00
abstract::The granulocyte macrophage colony stimulating factor (GM-CSF) promoter contains a 10 bp element known as CK-1 or CD28RE that specifically responds to the co-stimulatory signal delivered to T cells via the CD28 surface receptor. This element is a variant NFkappaB site that does not function alone but requires an adjace...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.12.1945
更新日期:1999-12-01 00:00:00
abstract::CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are requ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.12.2043
更新日期:1999-12-01 00:00:00
abstract::A central tenet of vaccine development is to identify immune correlates of protection. Both plasmid-encoded gD as well as recombinant protein gD can protect mice from lethal herpes simplex virus (HSV) challenge. It is known that different vaccine modalities should induce different immune phenotypes. Yet, paradoxically...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.11.1763
更新日期:1999-11-01 00:00:00
abstract::Specific antibodies increase antigen uptake and presentation by antigen-presenting cells via the B cell receptor in B cells or FcgammaR in dendritic cells. To determine whether the interaction between antibody and antigen could influence the set of peptides presented by MHC II molecules, we analyzed the presentation o...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.11.1863
更新日期:1999-11-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell-mediated, inflammatory disease with similarities to multiple sclerosis in humans. Intranasal (i.n.) administration of a myelin basic protein (MBP)-derived peptide can protect susceptible mice from EAE. The mechanisms underlying this phenomenon, however...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.10.1625
更新日期:1999-10-01 00:00:00
abstract::Recent studies point to glycolipid-enriched membrane (GEM) microdomains as the critical sites for TCR-mediated signal transduction. However, whether the TCR complex is localized in the GEM domain is not well-defined. In the present study, we analyzed localization of the TCR-CD3 complex in the GEM domain by isolating t...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.9.1395
更新日期:1999-09-01 00:00:00
abstract::Liver fibrosis is commonly observed in chronic liver disease. However, the immunological mechanisms underlying hepatic fibrosis due to chronic inflammation are not well defined, mainly because suitable experimental models have not been established. We have found that weekly i.v. administration of concanavalin A (Con A...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.9.1491
更新日期:1999-09-01 00:00:00
abstract::In contrast to most organs, the anatomy of the liver may allow naive CD8(+) T cells to make direct contact with liver parenchymal cells. We have previously shown, using a combination of TCR transgenic T cells specific for H-2 K(b) and hepatocytes expressing a transgenic H-2 K(b) molecule, that hepatocytes can induce a...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.8.1225
更新日期:1999-08-01 00:00:00
abstract::At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-) ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.8.1327
更新日期:1999-08-01 00:00:00
abstract::Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues. The mediator(s) of this maturation process has not been yet defined. We investigated th...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.7.1075
更新日期:1999-07-01 00:00:00
abstract::Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.7.1169
更新日期:1999-07-01 00:00:00
abstract::Cross-linking of the IgM antigen receptor on an immature B cell lymphoma (BKS-2) induces growth arrest and apoptosis. This is accompanied by down-regulation of the immediate early genes, egr-1 and c-myc, and a reduction in NF-kappaB activity. Anti-IgM-induced growth arrest and apoptosis of this murine B cell lymphoma ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.6.871
更新日期:1999-06-01 00:00:00
abstract::NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.6.957
更新日期:1999-06-01 00:00:00
abstract::Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.5.643
更新日期:1999-05-01 00:00:00
abstract::The TCR is responsible for the specificity of cytotoxic T lymphocytes (CTL) by recognizing peptides presented in the context of MHC. By producing recombinant soluble TCR, it is possible to study this interaction at the molecular level. We generated single-chain TCR (scTCR) from tumor infiltrating lymphocytes (TIL) and...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.5.745
更新日期:1999-05-01 00:00:00
abstract::The lectin complement pathway is initiated by binding of mannose-binding lectin (MBL) and MBL-associated serine protease (MASP) to carbohydrates. In the human lectin pathway, MASP-1 and MASP-2 are involved in the proteolysis of C4, C2 and C3. Here we report that the human MBL-MASP complex contains a new 22 kDa protein...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.5.859
更新日期:1999-05-01 00:00:00
abstract::Factors responsible for the predictable generation of Th1 or Th2 immune responses to microorganisms in vivo are not well characterized, although the ability of antigen presenting cells (APC) to provide co-stimulation, the kinetics of MHC-peptide ligand generation as well as the cytokine environment are all considered ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.4.481
更新日期:1999-04-01 00:00:00
abstract::The mucosa is one of the initial sites of group A streptococcal (GAS) infection and salivary IgA (sIgA) is thought to be critical to immunity. However, the target epitopes of sIgA and the function of sIgA in GAS immunity, in particular the role of accessory cells and complement, is largely unknown. We studied the aqui...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.4.569
更新日期:1999-04-01 00:00:00
abstract::In order to better understand the role of intestinal CD1d, we sought to define the cellular localization and further characterize the biochemical structure of CD1d in human intestinal epithelial cells (IEC). Using a CD1d-specific rabbit anti-gst-CD1d antibody, immunoprecipitation of radiolabeled cell surface proteins ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.3.383
更新日期:1999-03-01 00:00:00
abstract::Sera of patients suffering from systemic lupus erythematosus (SLE) frequently contain oligoclonal IgG autoantibodies with high affinity for the ribosomal protein L7 (rpL7). The humoral autoimmune response to rpL7 apparently is driven by antigen and T cell dependent. In order to analyze the T cell response to rpL7 we c...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.2.125
更新日期:1999-02-01 00:00:00
abstract::Sequestration of neutrophils and release of histotoxic mediators are considered important for the development of pathologic alterations of the lung defined as adult respiratory distress syndrome. Mechanisms of inflammatory lung injury caused by abdominal sepsis were investigated using the colon ascendens stent periton...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.2.217
更新日期:1999-02-01 00:00:00
abstract::Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.1.21
更新日期:1999-01-01 00:00:00
abstract::We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.12.1891
更新日期:1998-12-01 00:00:00